Monday, November 18, 2013

Concussion Healing Aided by Menstruation



Photo via askchiq.com  
               When you think of sports related concussions you probably think of men’s football, rugby, ice hockey, and other aggressive sports but, many wouldn’t jump to females suffering many concussions due to sports injuries as well. Well according to Dr. Bazarian at the University of Rochester Sport Concussion Clinic about 70% of the head injuries patients he sees are females. Women typically show longer recovery times than do men when faced with a head injury but, menstrual cycles could play a role in just how long.
                After receiving a head injury sex hormones are often immediately changed from the normal levels. This is due to the pituitary gland in the brain which can be shut down by a hit to the head. The pituitary gland is part of the endocrine system which releases several hormones such as luteinizing hormone (LH) and follicle stimulating hormone (FSH) which are both important to the regular menstrual cycle of females (Discovery Communications, LLC. , 2013). The pituitary is often called
Photo via WebMD
the "master gland” because it can influence a majority of all the other glands in the body; it has the ability to manufacture and store hormones that can be released, causing the stimulation of other glands (Discovery Communications, LLC, 2013). Researchers have determined that if the pituitary gland no longer produces and releases FSH and LH then the levels of estrogen and progesterone in the body will drastically drop (University of Rochester Medical Center, 2013). FSH and LH are an important part of the menstrual cycle and greatly affect the release of progesterone, as can be seen in the chart shown below.

                The hormone progesterone is a hormone in the human body that is produced in the ovaries, in the placenta after implantation of a fetus, and by the adrenal glands (National Women's Health Resource Center, 2013). Progesterone is important in preparing the body for conception and is also responsible for maintaining a regular monthly menstrual cycle (National Women's Health Resource Center, 2013). As is shown in the diagram, when the levels of progesterone are high the uterine lining is thickening, preparing for implantation and if an egg is not fertilized and implanted the levels of progesterone quickly drop and the lining will be broken down and removed via menses (National Women's Health Resource Center, 2013). The menstrual cycle is broken into the two weeks prior to menstruation and the two weeks after, including the seven day menses. The point you are in this cycle proves to be viable information for females recovering from concussion and other head trauma related injuries.


 
      Bazarian and his team took 144 women from age 18 to 60 that had just experienced a head injury within the past four hours. These women gave blood samples as soon as they arrived and their progesterone levels were calculated determining the phase of the menstrual cycle they were currently in (University of Rochester Medical Center, 2013). Based on progesterone levels all 144 females were placed into three groups: the first was women who were in the premenstrual phase; their progesterone levels were high. The second group tested low for progesterone, which indicated they are postmenstrual (University of Rochester Medical Center, 2013). The third and final group was those who reported being on birth control pills which have synthesized progesterone hormones and females taking birth control pills receive a constant flow of hormones (University of Rochester Medical Center, 2013).
                The researchers and Bazarian came up with the “withdrawal hypothesis” before proceeding with any additional follow-up tests. This hypothesis stated that if a woman suffers a concussion during the premenstrual period her progesterone levels are high and after the injury they are drastically dropped leaving her with symptoms such as headaches, nausea, dizziness, and other uncomfortable side effects (University of Rochester Medical Center, 2013). But, if she suffers a concussion after her menstrual cycle her progesterone levels are already drastically reduced naturally so the effects previously stated won’t apply to these females because the progesterone isn’t dropping dramatically (University of Rochester Medical Center, 2013). This should cause females in the premenstrual group to suffer longer after their injury while postmenstrual females recover quicker.
After one month these same 144 females were brought back to do follow-up testing to see if the different phases of menstruation and progesterone levels have effects on the slow recovery time females endure after head injury. Standardized tests were used to assess the women for their concussion recovery and their quality of life; they were asked questions about their mobility, daily activities, and the pains they experience (University of Rochester Medical Center, 2013). The women who were in the premenstrual phase were twice as likely to score worse on these tests as the postmenstrual women and those on the pill. Women in the birth control group has the highest scores overall than the other groups. These results concur with Bazarian’s “withdrawal hypothesis” but further testing needs to be done to conclude that birth control pills are even more advantageous to female athletes. Birth control pills are already popular among female athletes because of the predictable periods and the added protection for bones; if this data is another plus for birth control pills it will be one more reason for female athletes to use them.
AskChiq. (2010, December 08). Concussion symptoms differ between girls and boys. Retrieved from http://askchiq.com/fitness_health/5588432 
Discovery Communications, LLC. (2013). What does the pituitary gland do?. Retrieved from http://health.howstuffworks.com/human-body/parts/what-does-pituitary-gland-do.htm
National Women's Health Resource Center. (2013). Progesterone overview. Retrieved from http://www.healthywomen.org/condition/progesterone
University of Rochester Medical Center (2013, November 13). Menstrual cycle influences concussion outcomes. ScienceDaily, Retrieved November 16, 2013, from http://www.sciencedaily.com/releases/2013/11/131113130033.htm
WebMD. (2010, July 23). Pituitary gland. Retrieved from http://www.webmd.com/brain/pituitary-gland
Womack, L. (2013). Birth control and the female athlete. Retrieved from http://www.sportsmd.com/SportsMD_Articles/id/309.aspx
 

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